Overview of Chosen Chemical Compounds and Intermediates
Overview of Chosen Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity associated with bortezomib, a proteasome inhibitor Employed in the remedy of many myeloma. Its synthesis or analyze is very important for making certain the purity and security in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor inside the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate most cancers by inhibiting androgen output.
Imatinib Intermediate (CAS NO. 152460-10-one): A essential compound during the synthesis of imatinib, a drug that targets precise sorts of cancer, together with Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats different cancers for instance breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are generally intermediates during the synthesis of gemcitabine, an anti-most cancers drug. Their study is vital for optimizing the output process and making certain large purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is utilized to treat breast most cancers, and these intermediates are associated with its production.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist Utilized 17-diol 17-acetate in the procedure of breast most cancers. Many intermediates help in the synthesis of this drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers such as ovarian, breast, and lung cancer.
three. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Employed in the treatment method of colorectal most cancers and small cell lung cancer.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked to the synthesis of adamantane derivatives, which have a variety of programs, like antiviral Homes.
Vildagliptin Intermediates: Used in the manufacture of vildagliptin, an oral drug for kind two diabetes that inhibits the enzyme DPP-four to control blood sugar levels.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-1): This compound is linked to the synthesis of various gluconic acid derivatives, which might be Utilized in food items, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor from the CAS NO. 134790-39-9 synthesis of canagliflozin, a medication made use of to deal with variety two diabetic issues by inhibiting sodium-glucose co-transporter two (SGLT2).